KYOWA QUALITY Glutamine - Fights Muscle Catabolism and Modulates Growth Hormone

Glutamine is a neutral amino acid and is the most abundant amino acid found in human muscle and blood.

In fact, 60% of the free amino acid reserve in skeletal muscle cells is composed of glutamine.

Glutamine is known as a conditionally essential amino acid because during times of stress (physical activity is stress) the body needs it more to maintain blood and muscle glutamine stores.

Glutamine is a non-essential amino acid that makes up more than 50% of the amino acid pool.

Already in 1990, Perry-Billings et al., and in 1991, Calder and Newsholme, proved that glutamine significantly helps the immune system.

Strenuous sports training is an attack on our defense system, which must cleanse and repair the cellular terrain damaged by stress and/or private life.

Now, the immunocytes responsible for this task require a high amount of glutamine in the plasma, to assist them in this task.

Consequently, if the levels of this amino acid in the blood are normally low (because most of it is used by the cells of the small intestine), the available glutamine is not enough and therefore it must be extracted from our muscle mass.

This is because of leaky gut syndrome (SAPI or LGS), which is accompanied by a systemic inflammatory state, hyperreactivity of the immune system, and overload of the liver and nervous system.

The most common symptoms are intestinal ones such as bloating, diarrhea, and cramps, but general symptoms such as tiredness, lack of energy, allergies, and intolerances also often appear.

Glutamine therefore restores the correct intestinal non-permeability, caused by cereals, dairy products, legumes and stress.

Glutamine in muscles makes up only 5-7% of total protein, so our bodies produce it from other amino acids, slowly and inexorably depleting the lean mass we had worked so hard to build.

This "deleterious" use of glutamine depends above all on the increase in levels of cortisol, a glucocorticoid that is released in all cases of stress, whether pathological or induced by physical exercise.

If cortisol is high, the extraction and production of glutamine (but also of another
(glucogenic amino acid, alaline) is greatly increased, slowing or even preventing muscle growth.

The oral or parenteral administration of glutamine can therefore improve nitrogen balance, helping the athlete to increase lean mass (and in the sedentary it maintains lean mass by preventing weakening and aging), as the body uses the amino acid supplement instead of dismantling our muscle proteins.

Glutamic acid, produced in the brain from glutamine (it is the only amino acid that can pass the blood-brain barrier), performs two other fundamental functions:

• together with glucose, it is the fuel of brain cells;

• Combining with ammonia (which causes fatigue during exercise), it detoxifies the brain by reconverting to its primary form, glutamine. Ammonia in the liver is also eliminated by this important amino acid.

• The brain also benefits from the effects of glutamine, as the amount of glucose it can store is limited and if the levels of the amino acid are
adequate brain function can be improved.

Monosodium glutamate in common bouillon cubes and Chinese foods contains glutamic acid.

• Another function of glutamine is that on cell volume. As we have seen when talking about creatine, the increase in cell size can be the signal to start the
anabolic and anticatabolic stimuli.

• Glutamine, in animal studies, has been shown to be the strongest cell volumizer tested.

If human studies confirm this characteristic, supplementation with this amino acid for increasing muscle mass is destined to become routine.

Further actions of glutamine are:

• synthesis of Glutathione (an important antioxidant produced
from our body);
• transport of nitrogen and carbon atoms;
• Urea synthesis (liver);
• RNA synthesis;
• Glucose/Glycogen synthesis;
• component of the amino acid pool,
• metabolic fuel;
• it would reduce the desire for alcohol;
• it is used experimentally in the treatment of
• depression, peptic ulcers, epilepsy, schizophrenia and
• senility;
• modulates growth hormone levels

The combination of glutamine + branched-chain amino acids would seem to be the optimal one to obtain the best results.

In fact, as we have seen, after a hard training session, the body uses the few available reserves of glutamine and alanine to restore the previous balance.

It then begins to break down muscle proteins, but especially branched-chain amino acids, which, through the alanine-glucose cycle, are transformed into glucose to compensate for the depletion of muscle glycogen.

If you boost the branched chain with glutamine, the exhaustion of the
glucogenic reserves, significantly reducing muscle catabolism and promoting recovery.

Many athletes even report feeling the difference between products containing BCAAs alone and those combined with glutamine. The field results of this combination
They are extremely positive and encouraging.

Ingredients: Pure Micronized Glutamine - Kyowa Quality

100 gram powder pack - measuring spoon included in the pack

Recommended dosage: 3 grams per day in water